DDX3 Regulates the Innate Immune Response to Bone Sarcomas
Rachel Weil, Esteban Uceda Arias-Stella, Da Peng, Patrick Cahan, Natalie D. ter Hoeve, P. J. van Diest, Venu Raman, Poornima Gourabathini, Kimberly Q. McKinney, Kenzie Wells, Kaitlyn H. Smith, Jeffrey S. Huo, Javier E. Oesterheld, David Mark Loeb
This study shows that inhibiting DDX3 in sarcomas induces a Type I interferon response and reduces metastasis when combined with immunostimulant therapy in mouse models.
bioRxiv · Jul 2, 2026 · PreprintCancer Biology