The NaV1.5 auxiliary subunit FGF13 modulates channels by regulating membrane cholesterol independent of channel binding
Aravind R. Gade, Mattia Malvezzi, Lala Tanmoy Das, Maiko Matsui, Cheng-I Jonathan Ma, Keon Mazdisnian, Steven O. Marx, Frederick R. Maxfield, Geoffrey S. Pitt
This study shows FGF13 modulates VGSCs by regulating membrane cholesterol, independent of direct channel binding, and reveals its role in maintaining cholesterol distribution and VGSC localization at the intercalated disc.
Journal of Clinical Investigation · Aug 12, 2025Peer-reviewedBiophysics