Geoffrey S. Pitt

The paper uses zebrafish otic vesicles and mouse epididymis to study columnar epithelial cell division dynamics, revealing conserved and species-specific mechanisms of nuclear migration and division.

This study demonstrates that FGF13 is not secreted from neurons and remains intracellular, contradicting recent reports suggesting extracellular function.

This study shows FGF13 modulates VGSCs by regulating membrane cholesterol, independent of direct channel binding, and reveals its role in maintaining cholesterol distribution and VGSC localization at the intercalated disc.

This study shows FGF13 regulates Cx43 trafficking and cardiac impulse propagation without involving voltage-gated sodium channels.

The paper investigates the distinct roles of PRC2 subcomplexes in epigenetic repression and stem cell differentiation using human pluripotent stem cells.

This study identifies FGF13's role in seizure susceptibility through interneuron-specific knockout mice, revealing a sodium channel-independent mechanism involving K+ channel regulation.

This study describes the first natural history of Timothy syndrome, identifying common extra-cardiac features beyond cardiac issues.

This study shows that increased CaV1.2 Ca2+ signaling in tendon fibroblasts leads to tendon hypertrophy, increased collagen fibrillogenesis, and improved biomechanical properties.

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

The paper identifies brain-region specific splicing patterns at single-cell and spatial resolution in postnatal mice, revealing cell-type specific and region-specific isoform expression.