Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions
Suifang Mao, Rui Song, Shibo Jin, Song Pang, Aleksandra Jovanović, Adam Zimmerman, Peng Li, Xinying Wu, Michael F. Wendland, Kerry Lin, Wei-Chi Chen, Semil P. Choksi, Gang Chen, Michael J. Holtzman, Jeremy F. Reiter, , Lin He
This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.
bioRxiv · Jan 21, 2025 · PreprintDevelopmental Biology