Michael J. Holtzman

This study shows PLSCR1 enhances IFN-lambda signaling in ciliated airway epithelial cells, improving resistance to IAV infection.

This study identifies ATG14's role in preventing unscheduled pyroptosis in the oviduct, ensuring proper embryo transport during early pregnancy.

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

The paper identifies a first-in-kind MAPK13 inhibitor that corrects stem cell reprogramming and reduces muco-obstructive lung disease symptoms in mice.

This study identifies MAPK13 as a regulator of structural remodeling and disease after epithelial injury, showing its role in basal-epithelial stem cell hyperplasia and mucous metaplasia in both mouse and human models.

This study identifies LRP1 as a mediator of leptin transport across the blood-CSF barrier in the choroid plexus, coupled with the short-form leptin receptor, and shows its deletion leads to leptin resistance and obesity.

This study shows that β-CATENIN is essential for organizing fimbrial glia and guiding dentate gyrus development, but not for CR cell positioning.

This study shows that constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial identity in mice and human stem cell-derived organoids.

The paper identifies potassium-driven cerebrospinal fluid (CSF) clearance through the choroid plexus during a critical neurodevelopmental phase in mice, showing its role in preventing hydrocephalus.