Song Pang

Oncostatin M-driven leak in human endothelial cells with preserved tight junctions

This study identifies oncostatin M-driven vascular leak in human endothelial cells through nanoscale channel formation, distinct from junction disassembly, and highlights potential therapeutic targets.

The female larval fly CNS connectome: first draft

The paper releases a complete larval Drosophila CNS connectome with automated segmentations and highlights the need for improved machine vision for proofreading.

miR-34/449 miRNAs regulate choroid plexus ciliogenesis to control cerebrospinal fluid production

This study identifies miR-34/449 miRNAs as regulators of choroid plexus multiciliogenesis, showing their role in controlling cerebrospinal fluid production through modulation of Shh signaling.

Combining brain-wide activity imaging with electron microscopy reveals a distributed brain network for processing threatening somatosensory stimuli

The paper combines brain-wide activity imaging with electron microscopy to identify a distributed neural network for processing threatening somatosensory stimuli in Drosophila larvae.

BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

The paper identifies BLTP3A as a protein associated with late endocytic membranes and shows it interacts with the CASM pathway to respond to lysosome damage.

Cross-species comparative connectomics reveals the evolution of an olfactory circuit

This study uses cross-species connectomics to show that olfactory circuits have conserved core elements and species-specific rewiring linked to ecological differences.

The first complete 3D reconstruction and morphofunctional mapping of an insect eye

The paper presents the first 3D reconstruction of an insect compound eye using vEM, revealing cellular structure and specialized photoreceptors in the parasitoid wasp Megaphragma viggianii.

Structural and functional dissection of the Pacinian corpuscle reveals an active role of the inner core in touch detection

This study reveals that the inner core of Pacinian corpuscles, not the outer core, mediates rapid adaptation and frequency tuning in touch detection.

Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

The paper identifies periodic ER-PM junctions in dendrites that enable long-range Ca2+ signal integration through local spine activation and ryanodine receptor-dependent Ca2+ release.

Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch

This study uses 3D reconstructions of mechanosensory end organs to propose a unified mechanism for Aβ RA-LTMR activation through axon protrusions and Piezo2 distribution.

3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle

This study reveals the 3D architecture of avian Meissner corpuscles and identifies a bi-cellular mechanism where lamellar cells release neurotransmitters to trigger action potentials in afferents for touch detection.

En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics

The paper introduces methods to prepare Drosophila brains for high-throughput FIB-SEM connectomics, enabling faster and more accurate imaging of neural connections.

Enabling FIB-SEM Systems for Large Volume Connectomics and Cell Biology

This paper introduces enhanced FIB-SEM technology that significantly increases imaging volume and resolution, enabling large-scale connectomics and cell biology studies.

Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity

The paper shows that astrocytes detoxify fatty acids from hyperactive neurons through mitochondrial oxidation, protecting neurons from toxicity.

Cortical Column and Whole Brain Imaging of Neural Circuits with Molecular Contrast and Nanoscale Resolution

The paper combines expansion and lattice light sheet microscopy to enable high-speed, nanoscale molecular imaging of neural circuits across large volumes.