Lin He

This study identifies miR-34/449 miRNAs as regulators of choroid plexus multiciliogenesis, showing their role in controlling cerebrospinal fluid production through modulation of Shh signaling.

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

This study identifies Klf5 as a key regulator of bi-potential cell fate in mouse preimplantation embryos by controlling both ICM and TE specification genes.

The paper identifies a species-specific retrotransposon promoter that generates a conserved Cdk2ap1 isoform essential for preimplantation development across mammals.

This study develops a microfluidic immunoblot to measure protein expression in single embryos and blastomeres, revealing heterogeneity in DICER-1 isoforms and other proteins during preimplantation development.