A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome
Ah‐Ram Kim, Kerui Huang, Jared Lee Johnson, Tomer M. Yaron, Keven Wang, Lewis C. Cantley, Yanhui Hu, Norbert Perrimon
The paper constructs a structure-guided kinase-transcription factor interactome atlas using AlphaFold-Multimer predictions, revealing docking motifs and allosteric hotspots that regulate kinase activity and lipid metabolism.
bioRxiv · Oct 10, 2025 · PreprintBioinformatics