Lewis C. Cantley

BRCA2 loss drives a PKM1-dominant glycolytic state that is selectively lethal to pyruvate kinase activation

The paper shows BRCA2 loss leads to a PKM1-dominant glycolytic state that can be targeted with PKM activators to kill HRD tumors.

Mass Control Genes Buffer a Conserved Sublinear Scaling Law Linking Single-Cell Dry Mass to Mitochondrial Redox Efficiency

The paper measures single-cell dry mass and mitochondrial redox efficiency across species, finding a sublinear scaling law and identifying mass control genes.

Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss

This study shows that inhibiting fructose metabolism via KHKi reduces weight gain and enhances weight loss when combined with GLP-1 receptor agonism in mice.

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors

The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.

A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome

The paper constructs a structure-guided kinase-transcription factor interactome atlas using AlphaFold-Multimer predictions, revealing docking motifs and allosteric hotspots that regulate kinase activity and lipid metabolism.

Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions

The paper identifies molecular determinants for phosphotyrosine recognition in tyrosine kinases and shows their roles in tumor promotion and suppression.

Comprehensive evaluation of phosphoproteomic-based kinase activity inference

This paper evaluates kinase activity inference methods using phosphoproteomics data and benchmarking approaches, finding that curated kinase-substrate libraries significantly impact results.

Illuminating the Dark Cancer Phosphoproteome Through a Machine-Learned Co-Regulation Map of 26,280 Phosphosites

The paper constructs a co-regulation map of phosphosites using machine learning and phosphoproteomic data, revealing kinase-substrate associations and identifying potential therapeutic targets in cancer.

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.

Atlas of the Bacterial Serine-Threonine Kinases expands the functional diversity of the kinome

The paper classifies bacterial STK sequences into families and identifies distinguishing features, providing insights for drug discovery.

Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome

The paper identifies and validates tyrosine phosphorylation sites on metabolic enzymes using parallel phosphoproteomics and metabolomics in MCF10A cells.

Submitochondrial Protein Translocation in Thermogenic Regulation

The paper identifies stress-induced submitochondrial protein translocation as a mechanism regulating thermogenesis and obesity by mobilizing proteins from the mitochondrial inner membrane into the matrix.

A global atlas of substrate specificities for the human serine/threonine kinome

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.

Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain

This study characterizes the distribution and localization of PI5P4K and PI5P4Kβ in mouse and human brains, showing distinct expression patterns in different brain regions and cell types.