Loss of SATB1 Induces a p21 Dependent CellularSenescence Phenotype in Dopaminergic Neurons
Markus Rießland, Benjamin Kolisnyk, Tae Wan Kim, Jia Cheng, Jason Ni, Jordan A. Pearson, Emily J. Park, Kevin Dam, Devrim Acehan, Lavoisier S. Ramos-Espiritu, Wei Wang, Jack Yin Zhang, Jaewon Shim, Gabriele Ciceri, Lars Brichta, , Paul Greengard
This study shows that loss of SATB1 in dopaminergic neurons leads to cellular senescence through p21 activation, suggesting a role for senescence in Parkinson's disease pathology.
Cell stem cell · Sep 19, 2019Peer-reviewedNeuroscience