Markus Rießland

The paper identifies cell-type-specific SASP ligand-receptor pairs that mediate paracrine senescence spreading in human brain cells and shows that targeting these factors can prevent senescence spread.

This study shows that nuclear import defects drive cell cycle dysregulation in neurodegeneration by impairing nuclear import pathways and causing cell cycle re-entry in neurons.

The paper identifies cell type-specific senescence-associated transcriptional regulators in midbrain cell lines using PCA and regulatory network inference.

The paper identifies p53-mediated apoptosis and TNF-NFkB signaling as key factors limiting survival of grafted dopamine neurons and shows that adalimumab treatment improves their engraftment and function in a PD mouse model.

This study identifies a gene regulatory pathway involving SATB1, MIR22HG, and GBA that leads to glucocerebroside accumulation and cellular senescence in dopaminergic neurons, contributing to Parkinson's Disease and aging.

This study shows that loss of SATB1 in dopaminergic neurons leads to cellular senescence through p21 activation, suggesting a role for senescence in Parkinson's disease pathology.

The paper introduces TRiP, a method for cell type-specific ribosome profiling, and shows experience-induced changes in translation in mouse CA1 pyramidal cells.