The paper identifies ILF2/3 as a regulator of primate cell fate by suppressing Alu element editing, showing its role in preventing aberrant splicing and maintaining epigenetic stability.

bioRxiv · Mar 5, 2026 · PreprintGenetics

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Patrizia Pessina, Mika Nevo, Junchao Shi, Srikanth Kodali, Eduard Casas, Yingzhi Cui, Alicia Richards, Emily J. Park, Xi Chen, Florencia Levin-Ferreyra, Alejandra Rivera Tostado, Erica J. Stevenson, Nevan J. Krogan, Danielle L. Swaney, Qi-Long Ying, , Bruno Di Stefano

The paper profiles RNA content in P-bodies across vertebrate species, showing that RNA sequestration in condensates is linked to cell fate transitions through miRNA-dependent mechanisms.

Nature Biotechnology · Oct 28, 2025Peer-reviewedCell Biology

The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons

Taylor Russo, Benjamin Kolisnyk, B.S. Aswathy, Tae Wan Kim, Jacqueline Martin, Jonathan Plessis‐Belair, Jason Ni, Jordan A. Pearson, Emily J. Park, Roger B. Sher, Lorenz Studer, Markus Rießland

This study identifies a gene regulatory pathway involving SATB1, MIR22HG, and GBA that leads to glucocerebroside accumulation and cellular senescence in dopaminergic neurons, contributing to Parkinson's Disease and aging.

Aging Cell · Feb 1, 2024Peer-reviewedNeuroscience

Loss of SATB1 Induces a p21 Dependent CellularSenescence Phenotype in Dopaminergic Neurons

Markus Rießland, Benjamin Kolisnyk, Tae Wan Kim, Jia Cheng, Jason Ni, Jordan A. Pearson, Emily J. Park, Kevin Dam, Devrim Acehan, Lavoisier S. Ramos-Espiritu, Wei Wang, Jack Yin Zhang, Jaewon Shim, Gabriele Ciceri, Lars Brichta, , Paul Greengard

This study shows that loss of SATB1 in dopaminergic neurons leads to cellular senescence through p21 activation, suggesting a role for senescence in Parkinson's disease pathology.

Cell stem cell · Sep 19, 2019Peer-reviewedNeuroscience