Paul Greengard

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

The paper identifies region-specific astrocyte genes and pathways linked to Alzheimer's disease susceptibility using a network-guided approach and mouse gene expression data.

This study identifies neuron-glia signaling mechanisms underlying the delayed antidepressant response to SSRIs in mice using single-cell sequencing.

This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.

This study shows that deleting Presenilin 1 in microglia during development enhances memory and neuronal activity in mice, with effects dependent on GluN2B and mitigating Alzheimer's symptoms.

This study shows GSAP regulates amyloid beta production by modulating APP trafficking, specifically by affecting the immobile vesicle pool associated with amyloidogenic processing.

The paper identifies translational and splicing differences in dopaminoceptive neurons and highlights PGE2's role in enhancing D2 dopamine receptor function in the dorsal striatum.

This study identifies a functional gene module associated with selective neuronal vulnerability in Alzheimer’s disease using integrated molecular and genetic data from mice and humans.

The paper shows C99 accumulates in vulnerable neurons in Alzheimer’s disease and correlates with cognitive impairment, while beta-amyloid levels increase in both vulnerable and resistant areas.

This study shows that loss of SATB1 in dopaminergic neurons leads to cellular senescence through p21 activation, suggesting a role for senescence in Parkinson's disease pathology.

This study shows that knocking out 5-HT4R in mature hippocampal excitatory neurons leads to anxiety-like behaviors and neural dysfunction.

This study shows GSAP reduces Aβ production without affecting Notch1 cleavage, suggesting it modulates γ-secretase specificity through conformational changes in PS1.

This study identifies hippocampal D2R neurons that regulate feeding behavior and encode food location memory through a LEC->Hippocampus->Septal circuit.

The paper introduces TRiP, a method for cell type-specific ribosome profiling, and shows experience-induced changes in translation in mouse CA1 pyramidal cells.