The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons
Taylor Russo, Benjamin Kolisnyk, B.S. Aswathy, Tae Wan Kim, Jacqueline Martin, Jonathan Plessis‐Belair, Jason Ni, Jordan A. Pearson, Emily J. Park, Roger B. Sher, Lorenz Studer, Markus Rießland
This study identifies a gene regulatory pathway involving SATB1, MIR22HG, and GBA that leads to glucocerebroside accumulation and cellular senescence in dopaminergic neurons, contributing to Parkinson's Disease and aging.
Aging Cell · Feb 1, 2024Peer-reviewedNeuroscience