Inhibition of FicD-mediated AMPylation and deAMPylation by Isoprenoid Diphosphates
Aubrie Blevins, Wei Peng, Lisa N. Kinch, Zihan Monshad, Andrea G. Paredes, Christina Volz, Jared P. Rutter, Amanda K. Casey, Kevin G. Hicks, Kim Orth
This study identifies geranyl- and farnesyl-pyrophosphate as FicD inhibitors that differentially affect disease-causing variants, providing insights for therapeutic targeting of UPR.
Proceedings of the National Academy of Sciences · Mar 4, 2026Peer-reviewedBiochemistry