Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains
Arwen W. Gao, Gaby El Alam, Amélia Lalou, Terytty Yang Li, Marte Molenaars, Yunyun Zhu, Katherine A. Overmyer, Evgenia Shishkova, Kevin Hof, Maroun S. Bou Sleiman, Riekelt H. Houtkooper, Joshua J. Coon, Johan H. Auwerx
The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.
iScience · Jan 5, 2022Peer-reviewedSystems Biology