Maroun S. Bou Sleiman

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

The paper identifies genetic and dietary factors influencing intestinal inflammation in BXD mice, finding MUC4 and EPHA6 as potential mediators of IBD susceptibility.

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

This paper introduces revTWMR, a method to determine causal relationships between gene expression and complex traits, finding that traits more strongly influence gene expression than vice versa.

Gene-by-environmental modulation of longevity and weight gain in the murine BXD family

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice

This study examines how genetic background and sex influence metabolic responses to high-fat diet in mice, highlighting the role of mitochondrial function in physiological diversity.

Identifying gene function and module connections by the integration of multi-species expression compendia

The paper introduces GeneBridge, a method for imputing gene function and predicting module connections using multi-species expression data, and demonstrates its application across 1,700 datasets.

Commensal bacteria act as a broad genetic buffer in Drosophila during chronic under-nutrition

This study shows that the Drosophila facultative symbiont Lactobacillus plantarum buffers genetic variation under chronic under-nutrition, reducing phenotypic and gene expression variation.