Marte Molenaars

This study shows that acute inhibition of iron-sulfur cluster biosynthesis in mice leads to metabolic inflexibility, reduced adiposity, and glucose dyshomeostasis, with effects mitigated in aged mice.

The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.

This study shows glycine supplementation extends C. elegans lifespan and alters gene expression, with effects dependent on the methionine cycle.

This study shows that clk-1 mutations in C. elegans extend lifespan by repressing cytoplasmic protein translation, similar to insulin signaling reductions, and identifies TAF-4 as a repressor of polyribosome formation under these conditions.