Mitochondrial Dysfunction Rewires Macrophage Metabolism, Driving Pro-inflammatory Priming and Immune System Remodeling
Nikita Markov, Aref Hosseini, Timothée Fettrelet, Kevin Oberson, Anna I. Brichkina, Shída Yousefi, Carole Bourquin, Hans‐Uwe Simon
This study shows mitochondrial dysfunction in macrophages drives a pro-inflammatory metabolic shift, impairing M2 traits and promoting M1-like activation, with systemic immune consequences.
bioRxiv · Nov 1, 2025 · PreprintImmunology