Author

Hans‐Uwe Simon

University of BernORCID 0000-0002-9404-7736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anna I. BrichkinaiD· 1 shared Aref HosseiniiD· 1 shared Carole BourquiniD· 1 shared Kevin Oberson· 1 shared Nikita MarkoviD· 1 shared Shída YousefiiD· 1 shared Timothée FettreletiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Anna I. BrichkinaORCID

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1 paper

Recent·Most cited

Mitochondrial Dysfunction Rewires Macrophage Metabolism, Driving Pro-inflammatory Priming and Immune System Remodeling

Nikita Markov, Aref Hosseini, Timothée Fettrelet, Kevin Oberson, Anna I. Brichkina, Shída Yousefi, Carole Bourquin, Hans‐Uwe Simon

This study shows mitochondrial dysfunction in macrophages drives a pro-inflammatory metabolic shift, impairing M2 traits and promoting M1-like activation, with systemic immune consequences.

bioRxiv · Nov 1, 2025 · PreprintImmunology