Molecular basis of vitamin K-dependent protein γ-glutamyl carboxylation
Qihang Zhong, Dandan Chen, Jinkun Xu, Yao Li, Wanqiong Yuan, Yan Meng, Qi Wen, Qiwei Ye, Guopeng Wang, Kexin Pan, Chunli Song, Lin Tao, Jie Qiao, Jing Hang
This study reports cryo-EM structures of GGCX bound to VKDPs and vitamin K, revealing its dual-catalytic mechanism and disease-associated mutation clusters.
Cell Research · Sep 29, 2025Peer-reviewedBiochemistry