A GPCR-G protein-β-arrestin megacomplex induced by an allosteric modulator
Guodong He, Qinxin Sun, Xinyu Xu, Fang Kong, Shuhao Zhang, Kexin Ye, Xiaoou Sun, Xin Chen, Chuangye Yan, Xiangyu Liu
This study determines the structure of a GPCR-G protein-β-arrestin complex stabilized by an allosteric modulator, showing a novel binding mode that allows coexistence with G protein signaling.
bioRxiv · Mar 24, 2025 · PreprintBiochemistry