Author

Xinyu Xu

Center for Life SciencesORCID 0000-0001-9375-9742Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xinyu Xu4 papers · University of California, San Francisco

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Chuangye YaniD· 2 shared Fang KongiD· 2 shared Guodong HeiD· 2 shared Qinxin SuniD· 2 shared Shuhao ZhangiD· 2 shared Xiangyu LiuiD· 2 shared Xiaoou SuniD· 2 shared Brian K. ShoichetiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Chuangye YanORCID

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3 papers

Recent·Most cited

A pan-positive allosteric modulator that mediates sustainable GPCR activation

Qinxin Sun, Guodong He, Xinyu Xu, Fang Kong, Shuhao Zhang, Xiaoou Sun, Chuangye Yan, Xiangyu Liu

This paper identifies atazanavir as a pan-positive allosteric modulator that activates multiple Family A GPCRs and sustains G protein signaling through non-canonical mechanisms.

bioRxiv · Mar 24, 2025 · PreprintBiochemistry

A GPCR-G protein-β-arrestin megacomplex induced by an allosteric modulator

Guodong He, Qinxin Sun, Xinyu Xu, Fang Kong, Shuhao Zhang, Kexin Ye, Xiaoou Sun, Xin Chen, Chuangye Yan, Xiangyu Liu

This study determines the structure of a GPCR-G protein-β-arrestin complex stabilized by an allosteric modulator, showing a novel binding mode that allows coexistence with G protein signaling.

bioRxiv · Mar 24, 2025 · PreprintBiochemistry

The impact of Library Size and Scale of Testing on Virtual Screening

Fangyu Liu, Olivier Mailhot, Isabella Glenn, Seth F. Vigneron, Violla Bassim, Xinyu Xu, Karla Fonseca-Valencia, Matthew S. Smith, Dmytro S. Radchenko, James S. Fraser, Yurii S. Moroz, John J. Irwin, Brian K. Shoichet

This paper tests the impact of library size and testing scale on virtual screening by comparing results from 1.7 billion vs. 99 million molecule libraries against AmpC β-lactamase, finding improved hit rates and potency with larger libraries.

Nature Chemical Biology · Jan 3, 2025Peer-reviewedBiophysics