Fang Kong

The paper reports cryo-EM structures of Arabidopsis thaliana AUX1 in IAA-bound and IAA-free states, revealing the molecular mechanism of auxin binding and transport.

This paper identifies atazanavir as a pan-positive allosteric modulator that activates multiple Family A GPCRs and sustains G protein signaling through non-canonical mechanisms.

This study determines the structure of a GPCR-G protein-β-arrestin complex stabilized by an allosteric modulator, showing a novel binding mode that allows coexistence with G protein signaling.