Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer's disease
Jialiu Zeng, Kholoud Abd-Elraouf, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Lance M. O’Connor, Jonathan Indajang, Richard Reynolds, Anna M. Barron, Chih Hung Lo
This study shows defective lysosomal acidification contributes to TNFR1-mediated neuronal necroptosis in Alzheimer's disease and demonstrates that lysosome-acidifying nanoparticles can rescue this process.
bioRxiv · Oct 12, 2023 · PreprintNeuroscience