Richard Reynolds

This study shows defective lysosomal acidification contributes to TNFR1-mediated neuronal necroptosis in Alzheimer's disease and demonstrates that lysosome-acidifying nanoparticles can rescue this process.

This study shows that chronic lymphotoxin-alpha overexpression in rat meninges leads to lymphoid-like structures and neurodegeneration resembling multiple sclerosis.

This study shows that TNF-mediated necroptosis, not apoptosis, contributes to neuronal loss in Alzheimer's disease and is a potential therapeutic target.

This study identifies a link between Epstein Barr virus and multiple sclerosis through enrichment analysis of GWAS data and biological validation.

The paper identifies two distinct microglial phenotypes in progressive MS patients and a rat model, showing they differentially associate with neurodegeneration.

The paper shows that neuroinflammation in MS brains causes structural changes at the node of Ranvier, leading to axonal conduction failure.

The paper introduces the MS Atlas, a molecular map of brain lesion stages in progressive multiple sclerosis, providing transcriptomic profiles and tools for analysis.