Jialiu Zeng

The paper compares proteomic profiles of extracellular vesicles from different human neural cell types to identify cell-type-specific cargo and functional roles.

This paper uses single-particle STORM imaging to quantify membrane coating heterogeneity in cell membrane-coated nanoparticles and reveals cell-type-dependent coating outcomes.

This study evaluates a peptide-based inhibitor of TNFR1 signaling in a human TNF transgenic mouse model of RA, showing reduced inflammation and improved disease outcomes.

This study shows that targeting lysosomal pH with rapamycin or acidic nanoparticles restores mitochondrial function in GBA1-mutant Parkinson's disease neurons.

This study shows lysosome-acidifying nanoparticles rescue neuronal death in A30P α-synuclein models by restoring lysosomal function and autophagy.

This study shows defective lysosomal acidification contributes to TNFR1-mediated neuronal necroptosis in Alzheimer's disease and demonstrates that lysosome-acidifying nanoparticles can rescue this process.