Lance M. O'Connor

The paper updates a toolkit for genetic studies in C. briggsae by identifying indel variants and mapping mutations to genes using high-throughput sequencing.

The paper analyzes the genomic diversity of C. tropicalis, finding geographic correlation and hyper-divergent regions linked to environmental adaptation.

The paper presents a gap-free, telomere-to-telomere genome assembly for the C. briggsae AF16 strain, along with improved gene annotations and variant mappings.

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

This study shows defective lysosomal acidification contributes to TNFR1-mediated neuronal necroptosis in Alzheimer's disease and demonstrates that lysosome-acidifying nanoparticles can rescue this process.