Jonathan Indajang

Lysosome-acidifying nanoparticles rescue A30P α-synuclein induced neuronal death in cellular and Drosophila models of Parkinson's disease

This study shows lysosome-acidifying nanoparticles rescue neuronal death in A30P α-synuclein models by restoring lysosomal function and autophagy.

Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

This study shows that Scn2a haploinsufficiency impairs dendritic signaling and flexible decision-making in mice.

Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making

This study uses two-photon microscopy to show that NE and ACh transients have distinct spatiotemporal dynamics during decision-making in mice, with NE promoting exploration.

Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression

The paper classifies psychedelics and psychoactive drugs using brain-wide imaging of c-Fos expression and machine learning, achieving above-chance accuracy in drug identification.

Macrophages protect against sensory axon degeneration in diabetic neuropathy

This study shows that macrophages protect against sensory axon degeneration in diabetic neuropathy by delaying axonal loss through CCR2 signaling.

Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer's disease

This study shows defective lysosomal acidification contributes to TNFR1-mediated neuronal necroptosis in Alzheimer's disease and demonstrates that lysosome-acidifying nanoparticles can rescue this process.