Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.
Sonette Steczina, Saffie E. Mohran, Matthew Carter Childers, Timothy S. McMillen, Ateeqa Naim, Matvey Pilagov, Marica Dente, Kristina Bezold Kooiker, Christian Mandrycky, Khushi Tawde, Jennifer Hesson, Jing Zhao, Julie Mathieu, Josè Manuel Pioner, Michael A. Geeves, , Michael Regnier
This study investigates the R403Q mutation in beta-myosin heavy chain using porcine and human stem cell models, revealing altered contractile properties and mechanisms of hypercontractility and impaired relaxation.
Journal of Molecular and Cellular Cardiology · Oct 28, 2025Peer-reviewedBiophysics