Jennifer Hesson

The paper identifies altered microtubule post-translational modifications in hypertrophic cardiomyopathy and shows protein kinase A modulates microtubule repolymerization in patient-derived hiPSC-CMs.

This study investigates the R403Q mutation in beta-myosin heavy chain using porcine and human stem cell models, revealing altered contractile properties and mechanisms of hypercontractility and impaired relaxation.

This study uses topic modeling on scHi-C data to identify cell type-specific chromatin structural patterns and compartment structures.

This paper introduces DNase Hi-C and targeted DNase Hi-C methods for high-resolution mapping of chromatin interactions, overcoming limitations of traditional Hi-C techniques.

The paper compares epigenomic and 3D genome architecture between naive and primed human embryonic stem cells, showing differences in enhancer marking and chromatin domain organization.