Ionic Regulation of Mechanosurveillance and Metastasis via the MRTFA/KCNMB1 Axis
Alexa M Gajda, Mohamed Haloul, Vinay Pai, Keyvan Mollaeian, Khushi J Patel, Raymundo Rodríguez-López, Katie Beverley, Mark A. Sanborn, Kihak Lee, Caitlyn C. Castillo, Stephanie M. Wilk, Beata Maria Wolska, Faruk Hossen, Eron N Mendenhall, James C. Lee, , Ekrem Emrah Er
This study identifies KCNMB1 and potassium efflux as regulators of cellular stiffness in cancer cells, showing that BK channel activation reduces metastasis and enhances immune cell cytotoxicity.
Developmental Cell · Jun 1, 2026Peer-reviewedCancer Biology