Author

James C. Lee

University of Illinois ChicagoORCID 0000-0002-7173-4875Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

James C. Lee1 paper

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Faruk HosseniD· 2 shared Alexa M Gajda· 1 shared Beata Maria WolskaiD· 1 shared Caitlyn C. Castillo· 1 shared Ekrem Emrah EriD· 1 shared Eron N Mendenhall· 1 shared Irena LevitaniD· 1 shared Jalees RehmaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Faruk HossenORCID

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2 papers

Recent·Most cited

Ionic Regulation of Mechanosurveillance and Metastasis via the MRTFA/KCNMB1 Axis

Alexa M Gajda, Mohamed Haloul, Vinay Pai, Keyvan Mollaeian, Khushi J Patel, Raymundo Rodríguez-López, Katie Beverley, Mark A. Sanborn, Kihak Lee, Caitlyn C. Castillo, Stephanie M. Wilk, Beata Maria Wolska, Faruk Hossen, Eron N Mendenhall, James C. Lee, , Ekrem Emrah Er

This study identifies KCNMB1 and potassium efflux as regulators of cellular stiffness in cancer cells, showing that BK channel activation reduces metastasis and enhances immune cell cytotoxicity.

Developmental Cell · Jun 1, 2026Peer-reviewedCancer Biology

Endothelial Nucleoporin93 (Nup93) Maintains Vascular Function via Sun1-Dependent Regulation of RhoA-eNOS Signaling

Tung Nguyen, Yumna Z. Khan, Faruk Hossen, Riya Makim, Justin M. Banks, Julia Michalkiewicz, Michael A. Winek, Luis Henrique Oliveira de Moraes, James C. Lee, Shane Aaron Phillips, Monica Y. Lee

This study shows that endothelial Nup93 stabilizes Sun1, which regulates RhoA-eNOS signaling, maintaining vascular function and NO bioavailability.

bioRxiv · Jul 18, 2025 · PreprintCell Biology