Multi-OMIC analysis of brain and serum from chronically-stressed mice reveals network disruptions in purine metabolism, fatty acid beta-oxidation, and antioxidant activity that are reversed by antidepressant treatment
Peter J. Hamilton, Emily Y. Chen, Vladimir Tolstikov, Catherine J. Peña, Punit Shah, Kiki Panagopoulos, Ana Nicolle Strat, Deena M. Walker, Zachary S. Lorsch, Nicholas L. Mervosh, Drew D. Kiraly, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish, Eric J. Nestler
The paper analyzes multi-omic data from stressed mice to identify molecular disruptions linked to depression and shows antidepressants reverse these changes in specific brain regions.
bioRxiv · Dec 8, 2018 · PreprintNeuroscience