The paper identifies sex-specific regulation of stress susceptibility by the astrocytic gene Htra1 in mice and humans, showing differential effects on neuronal signaling and ECM integrity.

bioRxiv · Apr 12, 2024 · PreprintNeuroscience

Multi-OMIC analysis of brain and serum from chronically-stressed mice reveals network disruptions in purine metabolism, fatty acid beta-oxidation, and antioxidant activity that are reversed by antidepressant treatment

Peter J. Hamilton, Emily Y. Chen, Vladimir Tolstikov, Catherine J. Peña, Punit Shah, Kiki Panagopoulos, Ana Nicolle Strat, Deena M. Walker, Zachary S. Lorsch, Nicholas L. Mervosh, Drew D. Kiraly, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish, Eric J. Nestler

The paper analyzes multi-omic data from stressed mice to identify molecular disruptions linked to depression and shows antidepressants reverse these changes in specific brain regions.

bioRxiv · Dec 8, 2018 · PreprintNeuroscience

Zfp189 Mediates Stress Resilience Through a CREB-Regulated Transcriptional Network in Prefrontal Cortex

Zachary S. Lorsch, Peter J. Hamilton, Aarthi Ramakrishnan, Eric M. Parise, William J. Wright, Marine Salery, Ashley E. Lepack, Philipp Mews, Orna Issler, Andrew Thomas McKenzie, Xianxiao Zhou, Lyonna F. Parise, Stephen T. Pirpinias, Idelisse Ortiz Torres, Sarah E. Montgomery, , Eric J. Nestler

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.

bioRxiv · Sep 7, 2018 · PreprintNeuroscience