Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant
Hanife Sahin, Md. Shariful Islam, A Hyeon Lee, Irene Ponzo, Kilian Winiger, Andreas Reichl, Thomas Carell, Pascal Giehr
This paper develops a method to generate pure 5hmdC-DNA using a Tet3 double-mutant and reduction steps, enabling applications in epigenetic research and diagnostics.
Computational and Structural Biotechnology Journal · Dec 28, 2025Peer-reviewedBiochemistry