Micha Drukker

The paper maps scRNA-seq from stem cell-based axial organoids to a human embryo, revealing three origins of axial development and the neural bias of neuromesodermal progenitors.

The paper conducts a phylogenetic analysis of NEAT1 and MALAT1 lncRNAs to explore their structural and functional conservation across mammals.

This paper develops DuoMYC, a synthetic miniprotein that inhibits MYC-driven transcription by binding to E-Box DNA with high affinity and stability.

The paper identifies glycogen metabolism differences in pluripotent cells across species that influence neural differentiation speed.

The paper captures two human axial stem cell states and identifies regulatory networks and mechanisms underlying their maintenance and differentiation.

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.

The paper identifies LIN28A as a key factor in mRNA decay during epiblast morphogenesis, linking cell identity changes to embryonic growth through nucleo-cytoplasmic translocation.

The paper uses single-cell RNA sequencing to map transcriptional trajectories of human pluripotent stem cells differentiating into lung and hepatocyte progenitors, identifying key signaling pathways and alternative developmental paths.