Pascal Giehr

Epitranscriptomic control of stress adaptations in Escherichia coli

This study maps epitranscriptomic changes in E. coli under oxidative and acid stress, identifying RNA modifications that influence stress adaptation and survival.

Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant

This paper develops a method to generate pure 5hmdC-DNA using a Tet3 double-mutant and reduction steps, enabling applications in epigenetic research and diagnostics.

Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress

This study uses direct RNA sequencing to analyze RNA modifications in E. coli under heat stress, revealing changes in m5C, m6A, and m6,6A levels in rRNA and shifts in mRNA modification patterns.

Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States

The paper captures two human axial stem cell states and identifies regulatory networks and mechanisms underlying their maintenance and differentiation.

GwEEP - A comprehensive approach for genome-wide efficiency profiling of DNA modifying enzymes

GwEEP quantifies DNA modifying enzyme efficiencies using HPoxBS data, revealing dynamic changes in methylation and hydroxylation during cellular reprogramming and development.