De novo design of light-controlled conformational protein switches
Alexander T. Hilditch, Nicolas Manuel Goldbach, Chenxuan Liu, Luciano A. Abriata, Ann-Sophie Helene Kroell, Friederike C Reinhardt, Sabine Aschenbrenner, Natalia Gasilova, Sarah Carina Warrelmann, René Rasche, Yassine Faik, Kimali Pilet, Elisabetta Occelli, Sandrine Georgeon, Joseph H. Schmidt, , Bruno E. Correia
This paper computationally designs light-responsive proteins that undergo conformational changes upon light activation, enabling precise control of biological functions.
bioRxiv · Oct 28, 2026 · PreprintBiochemistry