Alexander T. Hilditch

This paper computationally designs light-responsive proteins that undergo conformational changes upon light activation, enabling precise control of biological functions.

This study computationally designs soluble analogues of animal and microbial rhodopsins, showing they are well-folded, thermostable, and retain retinal photocycle functionality.

This study describes a de novo designed polypeptide that forms phase-separated droplets and fibers, showing droplet maturation into β-conformations similar to pathological assemblies.

The paper designs genetically encoded polypeptides that form membraneless organelles in E. coli and use them to co-compartmentalise a functional enzyme pair.