A Goldilocks principle of JAK/STAT signaling governs airway epithelial homeostasis and stress adaptation in Drosophila
Xiao Niu, Christine Fink, Kimberley Kallsen, Leizhi Shi, Viktoria Mincheva, Sören Franzenburg, Ruben D. Prange, Jingjing He, Anita Bhandari, Iris Bruchhaus, Holger Heine, Judith Bossen, Thomas Roeder
This study shows that JAK/STAT signaling in Drosophila airway epithelia must be balanced to maintain homeostasis and stress adaptation, with both insufficient and excessive activity causing pathology.
bioRxiv · May 20, 2025 · PreprintCell Biology