Iris Bruchhaus

Distinct temporal patterns of liver immune responses to pathogenic and non-pathogenic Entamoeba histolytica clones

This study compares immune responses to pathogenic and non-pathogenic E. histolytica clones in mice, finding distinct temporal transcriptomic profiles linked to disease severity.

A system for functional studies of the major virulence factor of malaria parasites

The paper develops a system to study PfEMP1, a key malaria parasite virulence factor, by generating parasites expressing a single PfEMP1 variant and enabling genome edits to investigate its function.

JNK integrates immune and stress signals to balance apoptosis and proliferation in airway progenitors

This study identifies JNK as a key integrator of immune and stress signals in airway progenitors, balancing apoptosis and proliferation to maintain tissue homeostasis during inflammation.

A marsh samphire (Salicornia europaea) extract induces a strictly sex-specific, Tor-signaling-dependent extension of lifespan and exhibits anti-obesogenic properties

A marsh samphire extract extends female Drosophila lifespan and reduces body fat, with effects dependent on Tor signaling and counteracting intestinal barrier loss.

A Goldilocks principle of JAK/STAT signaling governs airway epithelial homeostasis and stress adaptation in Drosophila

This study shows that JAK/STAT signaling in Drosophila airway epithelia must be balanced to maintain homeostasis and stress adaptation, with both insufficient and excessive activity causing pathology.

Entamoeba histolytica extracellular vesicles drive pro-inflammatory monocyte signaling

This study shows that extracellular vesicles from Entamoeba histolytica drive pro-inflammatory monocyte signaling, contributing to male-biased immunopathology in amebic liver abscesses.

Cytoadhesion of Plasmodium falciparum-infected red blood cells changes the expression of cytokine-, histone- and antiviral protein-encoding genes in brain endothelial cells

The paper shows that Plasmodium falciparum-infected red blood cells alter gene expression in brain endothelial cells, activating immune and antiviral pathways, and increasing cytokine and angiogenesis-related genes.

Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severecases

The paper identifies PfEMP1 variants associated with severe malaria in first-time infected adults and non-severe cases using RNA-seq and var gene analysis.