Holger Heine

This study identifies JNK as a key integrator of immune and stress signals in airway progenitors, balancing apoptosis and proliferation to maintain tissue homeostasis during inflammation.

The paper identifies differential TLR8-dependent immune responses induced by two methanogenic archaea, showing distinct gene-class activation patterns controlled by NF-κB p65 and STAT1/2.

This study shows that JAK/STAT signaling in Drosophila airway epithelia must be balanced to maintain homeostasis and stress adaptation, with both insufficient and excessive activity causing pathology.

The paper shows FoxO factors in Drosophila, mouse, and human airway epithelial cells respond to stressors by nuclear translocation, with FoxO-dependent stress pathways altered in asthma across species.