Chia‐Chen Liu

The paper identifies epigenetic changes in Alzheimer's disease brains linked to tau pathology, highlighting oligodendrocyte gene perturbations as a potential common mechanism across tauopathies.

This study investigates changes in the UFMylation pathway in Alzheimer's disease brains, finding increased UFM1 conjugation and associations with pathological tau.

This study shows that the TREM2-H157Y mutation increases soluble TREM2 and reduces amyloid pathology in mice, suggesting a potential protective effect against Alzheimer's disease.

This study performs a genome-wide association study of brain biochemical phenotypes in Alzheimer's patients, identifying novel genetic loci and highlighting distinct genetic architectures for AD-related proteins.

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.