Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination
Bo-Ruei Chen, Thu N. Pham, Lance Dylan Reynolds, Nghi Doan-Phuong Dang, Yanfeng Zhang, Kimberly Manalang, Gabriel E. Matos-Rodrigues, Jason Romero Neidigk, André Nussenzweig, Jessica K. Tyler, Barry P. Sleckman
The paper shows senataxin and DNA-PKcs redundantly support NHEJ repair of RAG-induced DSBs during V(D)J recombination, with senataxin's function overlapping with RECQL5 and HLTF.
Science Advances · Jun 20, 2025Peer-reviewedCell Biology