Yanfeng Zhang

This study shows that extrachromosomal circular DNA (eccDNA) in the male germline can integrate into the genome and contribute to structural variations, with diabetes increasing eccDNA levels in sperm.

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.

The paper shows senataxin and DNA-PKcs redundantly support NHEJ repair of RAG-induced DSBs during V(D)J recombination, with senataxin's function overlapping with RECQL5 and HLTF.

This study identifies eccDNA in human male germline and links its abundance to chronic diseases through transcriptional activity and apoptosis signaling.

The paper identifies a novel risk variant rs1047643 and its association with B cell-specific super-enhancer activity in systemic lupus erythematosus through multi-omics analysis.