Author

Jessica K. Tyler

Weill Cornell MedicineORCID 0000-0001-9765-1659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

André NussenzweigiD· 2 shared Barry P. SleckmaniD· 2 shared Bo-Ruei CheniD· 2 shared Nina ArslanoviciD· 2 shared Zulong CheniD· 2 shared Anup VaidyaiD· 1 shared Bryan J. VentersiD· 1 shared Chelsea Peart· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

André NussenzweigORCID

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5 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedJul 3, 2026

Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes

Ujani Chakraborty, Emma Saccone, Grisel Cruz‐Becerra…·Jessica K. Tyler

The paper shows that different binding modes to the nucleosome acidic patch lead to distinct cellular outcomes, with overexpression of Dot5 and camelid antibodies causing growth, DNA repair, and heterochromatin defects.

DOI 10.1093/nar/gkag693

yeastexperimental assay

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Cell BiologybioRxivSep 2, 2025

Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

J Ignacio Gutierrez, Claudia Edgar, Jessica K. Tyler

1 citation

yeastimaging

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Cell BiologyScience AdvancesPeer-reviewedJun 20, 2025

Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination

Bo-Ruei Chen, Thu N. Pham, Lance Dylan Reynolds…·Barry P. Sleckman

The paper shows senataxin and DNA-PKcs redundantly support NHEJ repair of RAG-induced DSBs during V(D)J recombination, with senataxin's function overlapping with RECQL5 and HLTF.

2 citations

mouseDNA methylation

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Molecular BiologyeLifePeer-reviewedOct 11, 2024

Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression

Zulong Chen, Xin Wang, Xinlei Gao…·Jessica K. Tyler

2 citations

humanbulk RNA-seq

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Molecular BiologyeLifePeer-reviewedMay 9, 2022

DNA-PK Promotes DNA End Resection at DNA Double Strand Breaks in G0 cells

Faith C. Fowler, Bo-Ruei Chen, Nicholas Zolnerowich…·Jessica K. Tyler

The paper shows DNA-PK promotes DNA end resection in G0 cells but not in G1 or G2 phase cells, revealing a cell cycle-specific role in DSB repair.

22 citations

humanexperimental assay

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