Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system
Ekaterini Himonas, Anand Manoharan, Kiron Roy, Kevin M. Rattigan, Angela Ianniciello, Martha M. Zarou, Daniele Sarnello, Leenus Martin, Robert F. Shoemaker, David P. Sumpton, Saverio Tardito, Chris Halsey, G. Vignir Helgason
This study develops a physiological CSF-like medium to culture CNS-ALL cells, revealing autophagy as a critical survival mechanism in the CNS niche.
bioRxiv · Mar 12, 2026 · PreprintCancer Biology