Author

Saverio Tardito

Comprehensive Cancer Center ViennaORCID 0000-0002-5294-8683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

David P. SumptoniD· 3 shared Anand ManoharaniD· 2 shared Christina HalseyiD· 2 shared Ekaterini HimonasiD· 2 shared Engy ShokryiD· 2 shared G. Vignir HelgasoniD· 2 shared Alejandro Huerta UribeiD· 1 shared Alexander CollingsiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

David P. SumptonORCID

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3 papers

Recent·Most cited

Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system

Ekaterini Himonas, Anand Manoharan, Kiron Roy, Kevin M. Rattigan, Angela Ianniciello, Martha M. Zarou, Daniele Sarnello, Leenus Martin, Robert F. Shoemaker, David P. Sumpton, Saverio Tardito, Chris Halsey, G. Vignir Helgason

This study develops a physiological CSF-like medium to culture CNS-ALL cells, revealing autophagy as a critical survival mechanism in the CNS niche.

bioRxiv · Mar 12, 2026 · PreprintCancer Biology

Thiol Scarcity in Cerebrospinal Fluid Renders Leptomeningeal Acute Lymphoblastic Leukaemia Therapeutically Vulnerable to Ferroptosis

Nikolai Gajic, Rhona Christie, Shirley Lam, Tobias Ackermann, Ekaterini Himonas, Jonathan Josephs‐Spaulding, Anand Manoharan, Victoria D Assmann, Jordan Martin, Alexander Collings, Karen M. Dunn, Engy Shokry, Alejandro Huerta Uribe, Sharon Burns, David O’Connor, , Christina Halsey

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

bioRxiv · Dec 17, 2025 · PreprintCancer Biology

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

Michalis Gounis, America V. Campos, Engy Shokry, Louise E. Mitchell, Ruhi S. Deshmukh, Emmanuel Dornier, Nicholas Rooney, Sandeep Dhayade, Luis Pardo, Madeleine Moore, David Novo, Jenna M. Mowat, Craig Jamieson, Emily Jane Kay, Sara R. Zanivan, , Cassie J. Clarke

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

The Journal of Cell Biology · May 7, 2025Peer-reviewedCancer Biology