Author

Anand Manoharan

University of GlasgowORCID 0000-0002-8325-7375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Christina HalseyiD· 2 shared David P. SumptoniD· 2 shared Ekaterini HimonasiD· 2 shared G. Vignir HelgasoniD· 2 shared Saverio TarditoiD· 2 shared Alejandro Huerta UribeiD· 1 shared Alexander CollingsiD· 1 shared Angela IannicielloiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Christina HalseyORCID

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2 papers

Recent·Most cited

Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system

Ekaterini Himonas, Anand Manoharan, Kiron Roy, Kevin M. Rattigan, Angela Ianniciello, Martha M. Zarou, Daniele Sarnello, Leenus Martin, Robert F. Shoemaker, David P. Sumpton, Saverio Tardito, Chris Halsey, G. Vignir Helgason

This study develops a physiological CSF-like medium to culture CNS-ALL cells, revealing autophagy as a critical survival mechanism in the CNS niche.

bioRxiv · Mar 12, 2026 · PreprintCancer Biology

Thiol Scarcity in Cerebrospinal Fluid Renders Leptomeningeal Acute Lymphoblastic Leukaemia Therapeutically Vulnerable to Ferroptosis

Nikolai Gajic, Rhona Christie, Shirley Lam, Tobias Ackermann, Ekaterini Himonas, Jonathan Josephs‐Spaulding, Anand Manoharan, Victoria D Assmann, Jordan Martin, Alexander Collings, Karen M. Dunn, Engy Shokry, Alejandro Huerta Uribe, Sharon Burns, David O’Connor, , Christina Halsey

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

bioRxiv · Dec 17, 2025 · PreprintCancer Biology